GMRC cocktail regulate the intestinal flora of patients with sepsis invitro.

The modulation of the gut microbiome has been gaining traction as a novel and effective therapeutic approach for managing SIRS. Traditional Chinese medicine (TCM) herbal formulations have shown significant potential in treating inflammation-related disorders, including SIRS, by modulating gut microbiota. Xuanfeibaidu Formula (XFBD) is a first-line traditional Chinese medicine (TCM) formula used for COVID-19 patients.Small-molecule drugs offer new opportunities and has emerged as a new frontier for gut microbiome remodeling compounds (GMRCs) discovery and precision medicine. To investigate whether GMRC deriving from XFBD can regulate intestinal flora in patients with sepsis.