PRECLINICAL EVALUATION OF POLYHERBAL AS AN ANTI- ALZHEIMERS, BY USING IN-VITRO ANTICHOLINESTERASE ENZYME MODEL

Background: Alzheimers disease is a neurodegenerative brain condition that causes mild cognitive impairment and memory loss, eventually leading to dementia. With developments in medicine, there are now more people in the world trying to treat a wider range of illnesses. It has been discovered that traditional herbal treatment works well with little or no adverse effects.

Materials & Methods: There are certain chemical components in the polyherbal extract of liquorice, ginger, and hibiscus sabadariffa that have anti-Alzheimers properties.

Results & Discussion: The polyherbal extract of liquorice, ginger, and hibiscus sabadariffa has been shown to have significant inhibition up to 44.02% in the group treated with it, which supports the extracts anti-Alzheimers activity. This was determined through a dose-dependent study and statistical comparison using Graph Pad Prism, version 10.2.2 by two-way ANOVA.