Expression profiling of human aortic endothelial cells vs human dermal endothelial cells. Expression profiling of human aortic endothelial cells vs human dermal endothelial cells

Multiple myeloma cells display a reciprocal relationship with neighboring niche cells in the bone marrow, particularly vascular endothelial cells. This relationship drives disease initiation, progression, and therapy resistance, but the mechanisms underlying this interaction remain incompletely understood. We performed transcriptomic analysis of endothelial cells from multiple human tissues and analyzed their capacity to promote MM growth in order to discover novel regulators of MM pathogenesis. Overall design: 6 replicates of human aortic endothelial cells and 6 replicates of human dermal endothelial cells