Supplementary Material for: Systemic Therapy of Advanced/Metastatic Breast Cancer - Current Evidence and Future Concepts

Systemic therapy of metastatic breast cancer may include
chemotherapy, endocrine therapy, and targeted
therapies (e.g., antibody-based approaches). These
agents may be employed alone or in combination based
on the patient’s breast cancer subtype. Therefore, characterization
of the disease phenotype is necessary and
may include biopsy of the metastatic site. Novel therapeutic
approaches include immunologic therapies, PARP
inhibitors, PI3K inhibitors, and CDK4/6 inhibitors, which
are currently under investigation in clinical trials.