Enantioselective CuH-Catalyzed Anti-Markovnikov Hydroamination of 1,1-Disubstituted Alkenes

Enantioselective synthesis of β-chiral
amines has been achieved
via copper-catalyzed hydro­amination of 1,1-disubstituted alkenes
with hydroxylamine esters in the presence of a hydrosilane. This mild
process affords a range of structurally diverse β-chiral amines,
including β-deuterated amines, in excellent yields with high
enantio­selectivities. Furthermore, catalyst loading as low as
0.4 mol% could be employed to deliver product in undiminished yield
and selectivity, demonstrating the practicality of this method for
large-scale synthesis.