scRNAseq of spleen and atherosclerotic plaques from young and aged healthy and young and aged atherosclerotic mice. scRNAseq of spleen and atherosclerotic plaques from young and aged healthy and young and aged atherosclerotic mice

T cells change substantially with age and are involved in atherosclerosis. Aging is the strongest clinical risk factor for atherosclerosis so we profiled T cells in young and aged mice prior to atherosclerosis (healthy) and in young and aged atherosclerotic mice (diseased). Overall design: Spleens from 3-month or 18-month and atherosclerotic plaques from 5-month and 21-month female C57BL/6 mice were rendered into single cell suspension, enriched for CD3+ cells and sequenced.