Chemoinformatic Exploration of “Bioinspired Metabolomes” Illuminates Diacetyl Assembly Pathways Toward Nesteretal A‑Like Cage Molecules
收藏NIAID Data Ecosystem2026-03-13 收录
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An appealing and challenging cage structure along with an unusual biosynthetic pathway prompted us to explore an expeditious bioinspired one-pot total synthesis of nesteretal A. An unconventional strategy was chosen, and a cascade reaction starting from diacetyl was studied. Under organocatalytic conditions mimicking an aldolase, nesteretal A and a related cage analogue were anticipated by in silico metabolization, detected, targeted, and characterized.
创建时间：
2022-02-03
