*comparing between cases with and without EE;†comparing between diagnostic groups;# ≥3 cytogenetic aberrations.N.A., not applicable; w/o, without; AEL, acute erythroid leukemia; AML-MRC, AML with myel

Figshare2015-12-02 更新50

A novel ASXL1-OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies. ssRNA-seq

血液恶性肿瘤表观遗传学

肿瘤抑制机制

ASXL1 plays key roles in epigenetic regulation of gene expression through methylation of histone H3K27, and disruption of ASXL1 drives myeloid malignancies, at least in part, via derepression of poste

NIAID Data Ecosystem40

Epigenome analysis of patients with various myeloid malignancies including differential levels of 5-hydroxymethylcytosine. Homo sapiens

血液恶性肿瘤表观遗传学

5hmC生物标志物

TET2 is a close relative of TET1, an enzyme that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. The gene encoding TET2 resides at chromosome 4q24, in a region showing recurr

NIAID Data Ecosystem10

Epigenome analysis of patients with various myeloid malignancies including differential levels of 5-hydroxymethylcytosine

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