PLD3 and PLD4 limit autoinflammation through multiple sensors of RNA and DNA.
收藏Alliance of Genome Resources2026-08-01 收录
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Supplementary Figure 14. RNAseq analysis of Pld3-/-Pld4-/- liver. Poly A+ RNA from whole livers were compared using next generation sequencing and the genes showing significant differences in expression from control livers of age-matched mice were further analyzed. RNA-Seq analyses were performed to identify differentially expressed genes in two datasets (Experiment1 and Experiment2 respectively) with 12 samples in each. Each dataset has 4 conditions with n=3 mice per condition. Experiment 1. Comparison of liver RNAs from 2 week old C57BL/6, Pld3-/-, Pld4-/-, and Pld3-/-Pld4-/- mice. Experiment 2. Comparison of liver RNAs from 2 month old C57BL/6, Tlr9CpG11/CpG11, Tlr9CpG11/CpG11Pld3-/-Pld4-/- and Unc93b13d/3dPld3-/-Pld4-/- mice.
