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Inhibition of YAP in human HCC cells

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NIAID Data Ecosystem2026-03-11 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE121732
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In vertebrates, the evolutionary conserved Hippo pathway fine-tunes organ size under physiological conditions such as tissue regeneration through the transcriptional regulation of pro-proliferative and anti-apoptotic genes. Here we want to identify downstream effectors of YAP, which is the most important transcriptional activator of this pathway. Nonsense/Scrambled siRNA-transfected and gene-specific siRNAs (YAP1, YAP2) were transently transfected in HepG2 cells (20 nM each). Total mRNA was extracted 24 hours after transfection.
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2019-04-30
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