Global genomic profiling of HIF-1a-regulated genes in bone marrow B cells from OVX mice

HIF-1a works as a stress-induced transcription factor to induce target genes mediating cell proliferation, meabolism and inflammation. To gain new insights into HIF-1a biology, we used high-throughput sequencing to analyze global HIF-1a transcriptional networks in bone marrow B cells from OVX mice. ChIP-seq was performed to determine the genome-wide HIF-1a binding sites in bone marrow B cells from OVX mice. RNA-seq was used to define differentially expressed genes in bone marrow B cells from OVX mice and sham control mice.