Dynamic chromatin accessibility landscape changes following interleukin-1 stimulation

Genome-wide methods for examining chromatin modification provide detailed information on regulatory regions of the genome.  Dynamic modifications of chromatin allow rapid access of the gene regulatory machinery to condensed genomic regions facilitating subsequent gene expression.  Inflammatory cytokine stimulation of cells can cause rapid gene expression changes through direct signalling pathway-mediated transcription factor activation and regulatory element binding. Gene expression microarray SW1353 cells treated with IL-1 (n = 3) vs controls (n = 3)