Distributions of energy restriction exposure variables for CRC cases characterized by CIMP*, MSI, and sub-cohort members in the Netherlands Cohort Study on diet and cancer after 7.3 years of follow-up (1986-1993).

*CIMP status defined as ≥3/5 genes methylated according to the Weisenberger markers(CACNA1G, IGF2, NEUROG1, RUNX3, and SOCS1).†due to missing data for exposure variables, numbers may not add up to 4650, 167, 84 and 578, respectively.‡presented as number of sub-cohort members (% of total number of sub-cohort members in the exposure category).§presented as number of cases (% of total number of cases in the exposure category).¶Hunger Winter: it was assumed that individuals residing in a western area of the Netherlands, especially a western urban area during the Hunger Winter would have experienced the greatest degree of energy restriction; War Years: it was assumed that individuals who resided in an urban area during the mid-point of the War would have experienced the greatest degree of energy restriction; Economic Depression: it was assumed that individuals who had an unemployed father during the Economic Depression would have experienced a higher degree of energy restriction compared to those whose father was employed.