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Visualizing Dynamic Weak Interaction Networks of Fluorine Atoms within Proteins via NMR

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中国科学院兰州化学物理研究所科学数据中心2026-01-09 更新2026-01-17 收录
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The utilization of fluorine probes in protein research has advanced our understanding of the nature of macromolecules. The diverse activities of proteins are governed by intricate weak interaction networks, yet the experimental detection presents a challenge. Herein, we have developed an NMR analytical method based on quantum coherent operations to characterize the weak chemical bonds of fluorine atoms within proteins that are bound to metal fluorides or labeled with fluorinated amino acids. Our approach offers a fast-screening method for identifying a weak interaction network without requiring crystallization.
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中国科学院兰州化学物理研究所科学数据中心
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2026-01-09
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