Increased Sensitivity to Oxidative Challenges Associated with topA Deletion in Escherichia coli
收藏PubMed Central2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC94351/
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资源简介：
Deletion of topA in Escherichia coli was found to result in a higher level of killing after treatment with either hydrogen peroxide or N-ethylmaleimide. This effect on oxidative challenge response represents a new role for E. coli DNA topoisomerase I in addition to prevention of excessive negative supercoiling of DNA.
提供机构：
American Society for Microbiology (ASM)
