Crystal structure of VDR-LBD/partial agonist complex: 22S-hexyl analogue
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Crystal structure of VDR-LBD/partial agonist complex: 22S-hexyl analogue Descriptor: (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,3S)-3-(2-hydroxyethyl)nonan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidene-cyclohexane-1,3-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor,Vitamin D3 receptor Authors: Anami, Y, Itoh, T, Inaba, Y, Nakabayashi, M, Ikura, T, Ito, N, Yamamoto, K. Deposit date: 2015-07-04 Release date: 2015-11-18 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity. Bioorg.Med.Chem., 23, 2015
创建时间：
2015-07-04
