Age- and ApoE genotype-dependent transcriptomic responses to O3 in the hippocampus of mice. Age- and ApoE genotype-dependent transcriptomic responses to O3 in the hippocampus of mice

We earlier demonstrated that ozone an urban pollutant, accelerates AD-like neuropathology in aging male ApoE3 mice. In this study, we investigate hippocampal transcriptomic alterations in young and aged E3 and E4 mice following O₃ exposure to elucidate the molecular mechanisms underlying O₃-induced AD pathology specifically in old E3 male mice.