MR imaging of pediatric subjects with high-grade gliomas

The DFCI-BCH-BWH-PEDs-HGG 2023 dataset is a subset of the BraTS-PEDs 2023/2024 challenge. The DFCI-BCH-BWH-PEDs-HGG 2023 dataset includes a retrospective multi-institutional cohort of conventional/structural magnetic resonance imaging (MRI) sequences, including pre-and post-gadolinium T1-weighted (labeled as T1 and T1 CE), T2-weighted (T2), and T2-weighted fluid-attenuated inversion recovery (T2- FLAIR) images, from Boston's Children Hospital and Dana-Farber Cancer Institute (n=61). Inclusion criteria comprised pediatric subjects with histologically approved high-grade glioma, i.e., high-grade astrocytoma and diffuse midline glioma (DMG), including radiologically or histologically proven diffuse intrinsic pontine glioma (DIPG). Exclusion criteria consisted of (1) Images assessed as low quality or with artifacts that would not allow for reliable tumor segmentation. (2) Infants younger than one month of age.