Gene expression in the femur hip joint articular cartilage of 12-week-old Gnptg-KO mice. Gene expression in the femur hip joint articular cartilage of 12-week-old Gnptg-KO mice

Mucolipidosis type III is a rare disease caused by mutations in the GNPTG gene, encoding the gamma-subunit of GlcNAc-1-phosphotransferase. Since osteoarthritis and joint stiffness are typical symptoms of the disease, we aimed to investigate the role of the gamma-subunit on cartilage homeostasis. We used microarray analysis to compare the global gene expression in the articular cartilage of Gnptg-KO and wild-type mice. Overall design: 2 samples generated from pools of 6 mice per genotype were analyzed. 1st sample: Hip joint articular cartilage of 12-week-old WT mice. 2nd sample: Hip joint articular cartilage of 12-week-old Gnptg-KO mice.