Replication delay dramatically decreases rate of UV-induced mutations

NIAID Data Ecosystem2026-03-10 收录

DNA损伤修复机制

UV生物效应

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA479461 数据链接链接失效反馈

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资源简介：

Study how amount of time between UV-irradiation and replication affect mutation rate.

创建时间：

2018-07-03

Induction and Processing of the Radiation-Induced Gamma-H2AX Signal and Its Link to the Underlying Pattern of DSB: A Combined Experimental and Modelling Study

DNA损伤修复机制

放射治疗剂量优化

We present here an analysis of DSB induction and processing after irradiation with X-rays in an extended dose range based on the use of the γH2AX assay. The study was performed by quantitative flow cy

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Roles for the Transcription Elongation Factor NusA in Both DNA Repair and Damage Tolerance Pathways in Escherichia coli. Escherichia coli

DNA损伤修复机制

转录偶联修复

Here we report our observations that have led us to propose that the transcription elongation factor NusA promotes a novel class of transcription-coupled repair (TCR) in addition to its previously pro

NIAID Data Ecosystem50

Mutation Signatures of UV-treated DNA polymerase eta-deficient yeast

DNA损伤修复机制

紫外线诱变谱分析

This study contains the whole genome sequencing of DNA polymerase eta-deficient yeast treated with multiple exposures of UV light. The goal of the study is to better delineate role of pol eta in influ

NIAID Data Ecosystem40

FAN1 R507H-PCNA-DNA_minimum-dataset

DNA损伤修复机制

冷冻电镜结构解析

This minimum cryo-EM dataset is used in the research of 'Structural and molecular basis of PCNA-activated FAN1 nuclease function in DNA repair'.

Figshare2025-02-10 更新70

Polymerase ? and mismatch repair cooperatively determine the mutagenicity of a methylating agent

DNA损伤修复机制

甲基化剂致突变性

We characterised genome-wide mutations induced by the O6-dG-methylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in mouse embryonic fibroblasts, deficient for the Pol ? catalytic subunit REV3

NIAID Data Ecosystem50

Replication delay dramatically decreases rate of UV-induced mutations

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