猴头菇多糖的化学修饰及其生物活性研究进展

Hericium erinaceus polysaccharides as the main active component extracted from H. erinaceus have many biological activities such as anti-oxidation, anti-tumor, and immune regulation. However, there are some limitations in solubility, bioavailability and activity intensity of natural H. erinaceus polysaccharides. In recent years, certain progress has been made in the studies of chemical modification, and structural features, having effects on the biological activities of H. erinaceus polysaccharides. In this paper, the recent advances in the study of chemical modification and biological activities of H. erinaceus polysaccharides are summarized, and the chemical modification methods of H. erinaceus polysaccharides through introducing new functional groups to substitute hydroxyl groups on the polysaccharide chains are elucidated. The changes in the structure and physicochemical properties of the chemically modified H erinaceus polysaccharides are introduced, and the alterations in biological activities and the underlying mechanisms of the chemically modified H. erinaceus polysaccharides are analyzed and discussed. It is expected that this work might provide a theoretical basis for further exploration of modification of H. erinaceus polysaccharides.