Analysis of the mRNA expression of peripheral blood stem and progenitor cell markers in pancreatic neoplastic disorders. Database

Pancreatic cancer is one of the deadliest cancers, often diagnose at an advanced stage when treatment options are limited and not effective. This study aimed to identify specific genetic markers in the blood that could help detect pancreatic cancer. We analysed the expression of six genes in peripheral blood mononuclear cells from the patients with pancreatic cancer, neuroendocrine tumours, and healthy individuals. The results showed that three genes – NANOG, CK19 and INS – were significantly elevated in patients with pancreatic cancer compared to healthy controls. These genes were not elevated in patients with neuroendocrine tumours, suggesting that this phenomenon may be specific to pancreatic cancer. Additionally, CK19 was associated with inflammation, a common characteristic of pancreatic cancer. This research highlights the potential for using blood-based genetic markers to improve detection of pancreatic cancer. With further validation, this approach could pave the way for less invasive and more accessible diagnostic tools..