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Figshare2026-01-06 更新2026-04-28 收录
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IntroductionCongenital anomalies of the kidney and urinary tract (CAKUT) are a significant cause of pediatric morbidity and mortality, often leading to chronic kidney disease (CKD). Accurate glomerular filtration rate (GFR) assessment is crucial for effective management, but a gold-standard pediatric GFR estimation formula remains elusive. This study compared the bedside Schwartz, Chronic Kidney Disease in Children (CKiD-U25) creatinine, and European Kidney Function Consortium (EKFC) creatinine-based equations against measured GFR (mGFR) using technetium-99m-diethylenetriaminepentaacetic acid (Tc-99mDTPA) clearance.MethodsData were collected from 276 children with CAKUT at Dr. Soetomo Academic General Hospital. Estimated GFR (eGFR) was calculated using the bedside Schwartz, CKiD-U25, and EKFC equations. mGFR was determined using Tc-99mDTPA clearance, considered the gold standard. Correlation (Spearman rs), bias, and accuracy (P30, percentage of eGFR within 30% of mGFR) were assessed. Subgroup analysis was performed for children older than two years.ResultsBoth equations correlated significantly with mGFR (bedside Schwartz: r = 0.793; CKiD-U25: r = 0,793; EKFC: r = 0.745, p 2 years, correlations strengthened (bedside Schwartz: r = 0.804; EKFC: r = 0.835, p ConclusionThese findings suggest the both bedside Schwartz and EKFC could be a reliable tool for GFR estimation in this pediatric CAKUT population.
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2026-01-06
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