RNAseq based transcriptome analysis of proximal colon mucosa in pigs in response to krill oil supplement and Trichuris suis infection

Anti-inflammatory properties of omega 3 polyunsaturated fatty acids (PUFA) have been exploited in the prevention and management of inflammatory bowel diseases (IBD) with promising results. However, it remains unclear if PUFA play a significant role in the resolution of inflammation and promote mucosal healing. In this study, we attempted to understand the mechanisms through which krill oil (KO), a natural product rich in PUFA and potent antioxidant astaxanthin, modulates the gut microbiome and metabolome using multi-omics based approaches in in vitro and in vivo colitis models.

ω-3 多不饱和脂肪酸（PUFA）的抗炎特性在预防和管理炎症性肠病（IBD）方面已被充分利用，并显示出良好的效果。然而，PUFA 在炎症消退和促进黏膜愈合中是否扮演着显著角色尚不明确。在本研究中，我们试图通过体外和体内结肠炎模型，利用基于多组学的方法，探究富含PUFA和强效抗氧化剂虾青素的天然产物磷虾油（KO）调节肠道微生物组和代谢组的机制。