Analysis of mRNA profiling in sinonasal inverted papilloma

Sinonasal papilloma is the most common type of sinonasal tumor, with the inverted variant being the most frequent subtype. This variant is known for its potential for recurrence and propensity for malignant transformation. The aim of this study is to investigate the biomarkers and regulatory pathways involved in the development of sinonasal inverted papilloma (SNIP). Overall design: To determine the roles of these biomarkers, we performed RNA exome sequencing on two SNIP samples and their paired normal tissues to analyze gene expression differences.