Supplementary Material for: Baseline blood biochemical and immunological measures correlate with clinical features and treatment responses in late-life depression

Abstract: Introduction. The heterogeneity of late-life depression patients makes it difficult to predict their treatment response. Methods. Hundred LLD patients were stratified into clusters based on ten blood biochemical and immunological parameters measured at baseline. The treatment effectiveness and clinical characteristics of the resulting clusters were compared. Results. The resulting clusters of patients were significantly different in treatment response and in a number of clinical features. Conclusion. The study confirmed the link between activities of enzymes involved in energy and glutamate metabolism, antioxidant, and immune systems, and the response of LLD patients to therapy, as well as with their specific clinical characteristics.