DTU-Denmark: Thermophile protein dataset (>= 50 degrees Celsius)

This dataset contains all proteins expressed by thermophilic organisms with an average temperature optimum of ≥50 °C. Key takeaway:The dataset is broadly applicable to bioinformatics research that involves identifying thermostable proteins or studying thermophilic organisms. It serves as a valuable starting point for researchers searching for thermostable homologs of specific proteins, since proteins expressed by thermophiles naturally provide a strong baseline for thermostability. The list of thermophilic organisms used to construct the dataset was obtained from ThermoBase (https://togodb.org/db/thermobase). This dataset was generated by the DTU BioBuilders 2025 iGEM team, with the specific aim of identifying thermostable homologs of the nylon-6-degrading enzyme NylC. Further details are available on the Model page of the 2025 DTU BioBuilders Wiki:https://2025.igem.wiki/dtu-denmark/model The scripts used to generate this dataset are available in the team’s GitLab repository under the ThermoBase_dataset subfolder:https://gitlab.igem.org/2025/software-tools/dtu-denmark Also, be sure to check out the generative protein diffusion model (Axolotl), which was trained based on an altered version of this thermophile protein data:https://zenodo.org/records/17274294