Expression data of osimertinib tolerant H1975 cells. Expression data of osimertinib tolerant H1975 cells

Even after osimertinib is administered to lung adenocarcinomas with EGFR mutations, there are a few cells which survive, and these tolerant cells are considered to be the source of later recurrence. We used microarray analysis to explore the mechanism behind the tolerance to osimertinib in lung adenocarcinoma cells with EGFR mutations. Overall design: H1975 cells surviving 1 week after treatment with 0.5 µM osimertinib (OR) and naive H1975 cells cultured without treatment (C) were collected and RNA was extracted and hybridized on Affymetrix microarrays.