Top 15 SNPs associated with early onset extreme obesity from the Genome-Wide Human SNP Array 5.0 (lowest nominal p-values across four genetic models) and their confirmation using family-based association studies for the risk allele derived from the GWA data

1genes or transcripts according to the UCSC Genome Bioinformatics (http://genome.ucsc.edu/): FTO: fat mass and obesity associated; C20orf75: hypothetical protein LOC164312; TSHR: thyroid stimulating hormone receptor isoform 1; BC041448: Homo sapiens cDNA clone IMAGE:5170949, partial cds; PCSK2: Homo sapiens cDNA FLJ34186 fis; HLA-DQA2: major histocompatibility complex, class II, DQ; none: no gene 250 kb up- or downstream of the SNP, 2FBATs were all evaluated under additive genetic model (as it is e.g. unknown if a dominant model is also appropriate for the analysis of the family-based data), 3SNPs showed evidence for a deviation from HWE in founders (p ≤ 0.05), 4not genotyped due to strong linkage disequilibrium to other FTO SNPs, 5rs41492957according to NCBI Build 36.2