Human GAR transformylase in complex with GAR substrate and AGF103 inhibitor
收藏Protein Data Bank Japan2023-10-18 更新2026-04-19 收录
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Human GAR transformylase in complex with GAR substrate and AGF103 inhibitor Descriptor: GLYCINAMIDE RIBONUCLEOTIDE, N-{5-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]furan-2-carbonyl}-L-glutamic acid, SODIUM ION, ... Authors: Wong-Roushar, J, Dann III, C.E. Deposit date: 2020-07-18 Release date: 2021-03-31 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.091 Å) Cite: Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors Bioorg.Med.Chem., 37, 2021
创建时间：
2020-07-18
