DHCA is translocated from the mitochondrial matrix to the cytosol

DHCA (3alpha, 7alpha-dihydroxy-5beta-cholestanoate) is translocated from the mitochondrial matrix to the cytosol. The transporter that mediates its passage across the inner mitochondrial membrane has not been identified. In particular, despite the structural and functional similarities between DHCA and long chain fatty acids, searches for carnitine - DHCA have failed (Russell 2003). VLCS (SLC27A2), one of the enzymes that catalyzes CoA conjugation of DHCA, may also be present in peroxisomes, and Mihalik et al. (2002) have hypothesized that DHCA could be translocated unchanged from the mitochondrial matrix to the peroxisomal matrix and undergo conjugation there.

DHCA（3α, 7α-二羟基-5β-胆甾烷酸）可从线粒体基质转运至细胞质中。介导其穿过线粒体内膜的转运蛋白尚未被发现。特别是，尽管DHCA与长链脂肪酸在结构和功能上具有相似性，但针对肉碱-DHCA的搜索均以失败告终（Russell，2003年）。VLCS（SLC27A2），催化DHCA CoA缩合反应的酶之一，也可能存在于过氧化物酶体中，Mihalik等人（2002年）提出了假设，即DHCA可能未经改变地从线粒体基质转运至过氧化物酶体基质，并在那里进行缩合反应。