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Analysis of RNA expression under AhR antagonist treatment in human HSPCs

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NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP338687
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To examine the changes in RNA expression profile under AhR antagonist treatment in human hematopoietic stem progenitor cells (HSPCs), CD34+cells were isolated from umbilical cord blood (UCB) unit. CD34+cells were cultured with two different AhR antagonists CH223191 and StemRegenin1 (SR1) ex vivo for 7 days. cultured cells were used to perform RNA sequencing and analyze the changes in RNA expression profile by treatment. Overall design: Examination of 2 different Ary hydrocarbon receptor antagonists in cord blood (CB)-HSPCs (DMSO control vs. CH223191-treated vs. StemRegenin1-treated). Three biological replication of each group from identical individuals
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2022-06-02
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