A cost-effectiveness analysis of second-generation antihistamine 1 receptor blockers and Japanese kampo shoseiryuto for treatment of perennial allergic rhinitis in outpatient settings in Japan
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Objectives: Perennial allergic rhinitis (PAR) is common in Japan. Second-generation antihistamines (SGAs) are commonly used for its treatment; however, it remains unclear which SGA is the most cost-effective. Additionally, the pharmacoeconomics of Japanese Kampo shoseiryuto (which was traditionally prescribed to treat PAR in Japan) remains poorly understood. In this study, we aimed to investigate the effectiveness of various SGAs and shoseiryuto for the treatment of PAR in Japanese outpatients, from the healthcare payerâs perspective. Methods: The most cost- and clinically effective SGAs were determined from a list of six SGAs (bepotastine, 10 mg; cetirizine, 10 mg; ebastine, 10 mg; epinastine, 20 mg; loratadine, 10 mg; and olopatadine, 5 mg) together with shoseiryuto, using the overall improvement rate through a model-based analysis. The time horizon was 28 days. Costs were determined based on the Medical Fee Index in 2020. Deterministic and probabilistic sensitivity analyses were con..., , , # Title of Dataset: A Cost-Utility Analysis of Oral Triptans for Migraine in an Adult Outpatient Setting in Japan --- Author(s) Naoto Nakagawa, Phar.D., Ph.D. School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima, Japan 31-1 Misumido, Tomita-machi, Koriyama, Fukushima 963-8611, Japan Email: [n-nakagawa@pha.ohu-u.ac.jp](mailto:n-nakagawa@pha.ohu-u.ac.jp) Masami Kashiwabara, B.S., R. Ph, Qol Holdings Co., Ltd. Email: [m-kashiwabara@qol-net.co.jp](mailto:m-kashiwabara@qol-net.co.jp) Kei Egawa, B.S. School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima, Japan 31-1 Misumido, Tomita-machi, Koriyama, Fukushima 963-8611, Japan Email: [716008@ohu-u.jp](mailto:716008@ohu-u.jp) Ayaka Sasaki, B.S., R. Ph. School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima, Japan 31-1 Misumido, Tomita-machi, Koriyama, Fukushima 963-8611, Japan Email: [717045@ohu-u.jp](mailto:717045@ohu-u.jp) **File list** \_Input data Parameters for sensitivity analyses *...
