Transcriptome analysis of leukemic granulocyte/macrophage progenitors (L-GMPs) from MLL-AF9-transduced Jmjd3+/+ and Jmjd3-/- cells (Jmjd3-/- L-GMPs vs Jmjd3+/+ L-GMPs). Mus musculus

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https://www.ncbi.nlm.nih.gov/bioproject/PRJDB5604

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JMJD3 is a demethylase for histone H3K27. To analyze the role of JMJD3 in hematopoiesis and leukemogenesis, we generated conditional knockout (Jmjd3-/-) mice for JMJD3. We found that loss of JMJD3 in L-GMPs delays the onset of MLL-AF9-mediated acute myeloid leukemia in a mouse BMT model.

创建时间：

2022-03-14