Transgenerational effects of tetracyclines on the microbiome of the Australian sheep blowfly (Lucilia cuprina)

The purpose of this study was to examine the within- and trans-generational effects of two tetracycline-class antibiotics, doxycycline and anhydrotetracycline, on the microbiome of the Australian sheep blowfly (Lucilia cuprina). We found that both antibiotics exerted strong transgenerational effects on the diversity and composition of the fly microbiome. These findings are relevant to the field of genetic pest management, where tetracyclines are often used to control the expression of female-lethal genes.