Enantioselective Epoxidation of β,γ-Unsaturated Carboxylic Acids by a Cooperative Binuclear Titanium Complex

Enantioselective
epoxidation of β,γ-unsaturated carboxylic
acids with a cooperative binuclear titanium complex has been developed
to provide single diastereomer γ-lactones in high yields and
enantioselectivities via intramolecular cyclization. For the success
of the reaction, the proper distance between the carboxylic acid and
alkene is quite important, offering the regioselective epoxidation
of unsaturated carboxylic acids bearing two similar alkenes.