Gene expression changes in older adults post-Shingrix vaccination

This study investigates the post-vaccination gene expression associated with protective T cell levels and why it takes two doses to boost an anamnestic response in older adults using the AS01b-adjuvanted recombinant zoster vaccine (RZV, ShingrixTM). The experiment is the transcriptional profiling of peripheral blood mononuclear cells (PBMCs) from 15 healthy adults with age 50 – 65 years old collected at day 0, day 1, day 4 and day 14 post-dose 1 and day 60, day 61, day 64 and day 74 post-dose 2.