Gene expression profiling of tuberculosis patients from India

Whole genome microarray expression profiling was employed to identify differential gene expression profiles characteristic of tuberculosis patients in the South-Indian cohort. Whole blood samples were extracted from tuberculosis patients at the time of diagnosis and from healthy controls. The experiment served to validate computational predictions from a meta-analysis study of host transcriptional profiles in tuberculosis. Gene expression in human blood was measured from TB patients immediately after diagnosis and from corresponding healthy controls