Functional estimates of integrins in the integrin signaling networks.

Functional estimates of integrins in the integrin signaling networks of the HNSCC transcriptome were highly correlated to the percentage of matrix contraction due to knockdown of integrins with siRNA in stromal fibroblasts, which in turn should promote the invasion of the co-cultured oral cancer cells, SCC12. The percentages of matrix contraction due to siRNA depletion were formerly reported by Gaggioli and colleagues [1]. The higher the informational score, i.e. the lower percentage of matrix contraction due to knockdown of siRNA, indicated a more significant role in the invasion process.Pearson correlation coefficient = ?0.86 P-value = 0.005.*Informational scores were derived from the topological analysis of the integrin signaling networks of the HNSCC transcriptome in TvN.