Genetic Determinants of Susceptibility to Severe COVID-19 Infection

The goal of the project is to identify genetic susceptibility variants associated with acute COVID-19 infection susceptibility and severity using whole genome sequencing. The target of the project will include WGS data from whole blood samples of up to approximately 2000 COVID-19 patients (including critical/severe patient subgroup, asymptomatic/mild subgroup) from domestic and international medical institutions.]]>
Inclusion criteria: Patients eligible for this study have been either hospitalized for severe or critical (characterized by an ICU admission for requirement of high-flow oxygen therapy, mechanical ventilation, or ECMO) life-threatening COVID-19 infection, or those who have experienced asymptomatic/mild disease as confirmed by laboratory testing. Younger patients or those who have been previously healthy will be prioritized.]]>