Alternate “Drug” Delivery Utilizing β‑Lactam Cores: Syntheses and Biological Evaluation of β‑Lactams Bearing Isocyanate Precursors
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https://figshare.com/articles/dataset/Alternate_Drug_Delivery_Utilizing_Lactam_Cores_Syntheses_and_Biological_Evaluation_of_Lactams_Bearing_Isocyanate_Precursors/4488053
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The synthesis of a small set of β-lactams containing isocyanate precursors is described. The release of the isocyanate precursor in model hydrolysis experiments was substantiated by trapping experiments, thus confirming that β-lactams can be designed that are capable of releasing alternatively reactive species. Preliminary biological assessments are also briefly discussed.
创建时间：
2016-12-21
