UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE103567
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In this project we analyze the transcriptome of the human multiple myeloma isogenic cell lines ARP-1 (UTX wild-type) and ARD (UTX null). The transcriptome is studied at baseline, upon restoration of UTX levels in ARD cells for 3 and 6 days, and upon treatment of the cell lines with the EZH2 inhibitor GSK343. Moreover, we analyzed the transcriptome of a ARD resistant cell line that we generated. Examination of transcriptome of two cell lines upon restoration of UTX and treatment with EZH2 inhibitors
创建时间：
2019-05-15
