Expression data of lncRNAs and mRNAs extracted from serum of tuberculosis patients and healthy individuals

Efforts to eradicate TB are largely threatened by drug-resistant tuberculosis, particularly, multidrug-resistant tuberculosis (MDR-TB). It is imperative to find one or more specific biomarkers for diagnosing MDR-TB earlier and declining the incidence. Growing evidences have showed lncRNAs are widely expressed and take part in the genesis and development of many diseases, including tuberculosis. Therefore, to screen the differential lncRNAs among MDR-TB, drug-sensitive tuberculosis(DS-TB) and healthy controls(HCs) is a good strategy to acquire potential biomarkers for MDR-TB diagnosis and partly describe the mechanism of MDR-TB. Here, the present study aimed to investigate the differential expression profile of lncRNAs in serum among patients with MDR-TB ,DS-TB and HCs using lncRNA microarray From Jun 2020 to Feb 2021, hospitalized patients who were diagnosed with MDR-TB and DS-TB were recruited and healthy subjects came from physical examination donors with normal laboratory results and normal computed tomography chest films. Expression profiling studies were performed on the RNA from four independent serum samples in the group of MDR-TB,DS-TB and healthy controls.