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Coxsackievirus B (CVB) infection can result in a range of clinical manifestations, including myocarditis, pancreatitis, and encephalitis. Tyrosine kinase 2 (<i>ABL</i> proto-oncogene 2, ABL2) is a nonreceptor tyrosine-protein kinase that regulates various physiological processes and is involved in the infection processes of pathogenic microorganisms. However, the exact role of this factor in viruses, especially RNA viruses, is yet to be elucidated.