Primary structure of phylloseptins-S identified in the skin of P. sauvagii.

Identical amino acid residues are indicated in bold. a: amide; : Hydrophobicity; : Hydrophobic moment. The net charge (pH 7.4) and the original HPLC fraction are indicated. ND: not detected. The C-terminal amidation of PLS-S3 and -S5 is based on the presence of the Gly residue (amide donor) at the C-terminus of the PLS precursor and on the fact that all members of the PLS family are amidated.