Transcriptome Analysis of the cadiomyoocytes derived from Rett syndrome patent-specific Isogenic induced Pluripotent Stem Cell

Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by MeCP2 mutation. However, the pathophysiological roles of MeCP2 mutation in the aetiology of QT prolongation and sudden death remain unclear. Here, we performed RNA sequencing-based transcriptome analysis in a pair of isogenic RTT female patient-specific induced pluripotent stem cell derived-cardiomyocytes (iPSC-CMs) that expresses either MeCP2wildtype or MeCP2mutant allele, and iPSC-CMs from a non-disease female control. The result revealed up-regulation of various WNT family genes in MeCP2mutant iPSC-CMs. mRNA profiles of isogenic iPSCs-derived cardiomyocytes expressing wildtype or mutant MeCP2 allele. Additional line from normal female was also included for comparison