Transition-Metal-Free Dehydrosilylative Difluoroamidation of Tetrahydroisoquinolines under Mild Conditions

Disclosed herein is a dehydrosilylative difluoroamidation of α-Csp3–H of tetrahydroisoquinolines with α,α-difluoro-α-TMS-acetamides. The process, which occurs at ambient temperature in the absence of any transition metals, provides direct access to a broad range of α,α-difluoroacetamide-substituted tertiary amine derivatives in high yields. Moreover, the method was successfully applied in the Csp3–H-directed difluorophosphorylation and difluorocarboxylation under the same conditions.