Univariate and logistic regression analysis for factors associated with treatment failure in 528 chronic hepatitis C genotype 1 patients.

Note: IL28B, interleukin-28B gene; SD: standard deviation; OR: odds ratio; CI: confidence intervals; SVR: sustained virological response; EVR: early virological response; AST: aspartate aminotransferase; ALT: alanine aminotransferase; APRI: aspartate aminotransferase-to-platelet ratio index.*defined as W410,000 IU/mL/non-TT genotype. Odds ratio of treatment failure are for age (per year increase), sex (male vs. female), body weight (per kilogram increase), EVR status (no vs. yes) and poor week 4 responses, treatment week 4 HCV RNA10 IU/mL decline or >10,000 IU/mL combined with IL28B non-TT genotype (yes vs. no).