Figure S1 - Hypoxic Tumor Environments Exhibit Disrupted Collagen I Fibers and Low Macromolecular Transport

Establish tumor orientation. (A) An anesthetized mouse shown with agarose gel embedding. Liquid agarose was poured into the cylindrical holder around the tumor which solidified at room temperature. The entire tumor was embedded in agarose gel and asymmetrical cuts were made in the surrounding agarose gel before acquiring the MR images. (B) M0 MRI maps of cross-sectional images of the tumor. The asymmetrical cut (shown by red arrows) is seen in all the M0 maps of the tumor.
(PPTX)