Comparing gene expression profiles of HCmel3 mouse melanomas treated (early-during-treatment, EDT d12-d20 after ACT onset) with gp100-specific adoptive pmel-1 T cell transfer (ACT) versus non-treated control HCmel3 melanomas

This data was also integrated with gene expression profiles from late relapse tumors (GSE40213) to compare changes from early-during-treatment to late relapse versus non-treated. These re-analyzed samples are available in this series. In EDT samples we observed typical changes consistent with an effective anti-tumor T cell response including CD8 T cell infiltration, interferon pathway activation and downregulation of proliferation associated gene sets. Total RNA was isolated from excised and liquid nitrogen frozen tumors and global gene expression was performed using the Illumina Mouse WG6 v2.0 platform.